If you are on the hunt for a delicious, crowd-pleasing dish that’s just bursting with flavor and texture, this Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe is an absolute game changer. Creamy, cheesy, and topped with a perfectly golden crunchy crust, it’s the kind of casserole that warms the heart and satisfies every craving. Whether it’s a family dinner or a special gathering, this recipe comes together with simple ingredients that pack an unforgettable punch.

Ingredients You’ll Need
Gathering these straightforward but essential ingredients is your first step to creating the ultimate shrimp casserole. Each item has a distinct role, from tender shrimp to the crispy panko topping, making every bite perfectly balanced with flavor and texture.
- Large shrimp (21-24 count), peeled and deveined: The star protein, offering a sweet and succulent base for the casserole.
- Old Bay seasoning: A classic seasoning that infuses the shrimp with that signature savory spice blend.
- Salt for cooking water: Enhances the shrimp’s natural flavor during boiling.
- Mayonnaise: Adds creaminess and helps bind all the flavors together.
- Garlic powder: Delivers a gentle, aromatic kick without overpowering the dish.
- Ground black pepper: Brings a subtle heat and depth to the flavor profile.
- Butter: Used both for greasing the casserole dish and for the luscious topping.
- Panko bread crumbs: Creates that crave-worthy crispy, golden crust on top.
- Shredded mozzarella cheese: Offers a mild, melty stretchiness that complements the cheddar.
- Shredded medium cheddar cheese: Adds sharpness and richness, boosting the cheesy goodness overall.
How to Make Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe
Step 1: Preheat and Prepare Your Dish
Start by heating your oven to 375°F (190°C). While it warms up, generously grease a 2 1/2 quart casserole dish with butter to prevent sticking and ensure that buttery flavor touches every bite.
Step 2: Cook the Shrimp
Fill a large pot with water and bring it to a boil, then add salt and Old Bay seasoning. The seasoned water gives the shrimp an instant flavor boost. Drop in the shrimp and cook just until they turn opaque—about 30 seconds. Overcooking can toughen the shrimp, so keep a close eye. Once cooked, drain and set them aside.
Step 3: Combine the Ingredients
In a bowl, toss the shrimp with mayonnaise, garlic powder, and black pepper until every piece is coated lovingly. Next, fold in the shredded mozzarella and cheddar cheeses. This mixture will form the creamy, cheesy heart of your casserole. Then spread the mixture evenly into your prepared casserole dish.
Step 4: Make the Panko Topping
Melt butter in a small pan, then stir in the panko bread crumbs to coat them evenly. This buttery breadcrumb mixture is the secret to that irresistible crunchy topping. Sprinkle it generously over the shrimp and cheese filling.
Step 5: Bake to Perfection
Bake your casserole uncovered for 13-15 minutes, or until the internal temperature hits 145°F and the filling is bubbly. For that golden, toasty finish, switch your oven to broil and brown the topping for 1-2 minutes. Keep a close eye to avoid burning! Once done, let the casserole rest for 15 minutes before serving to allow the flavors to settle and the cheese to firm up slightly.
How to Serve Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe

Garnishes
Lightly sprinkle fresh parsley or finely chopped green onions over the casserole for a vibrant pop of color and a fresh, herbal note that contrasts beautifully with the rich cheese and tender shrimp.
Side Dishes
This casserole shines with simple side dishes such as a crisp green salad, roasted vegetables, or even buttery garlic bread. These sides will complement the creamy, cheesy shrimp without overwhelming its delicate flavor.
Creative Ways to Present
For a fun twist, serve the casserole in individual ramekins to give it a charming, personal touch. Alternatively, pair portions with steamed jasmine rice or creamy mashed potatoes to soak up every delicious bit of the cheesy sauce.
Make Ahead and Storage
Storing Leftovers
Keep any leftover shrimp casserole covered tightly in the refrigerator for up to 3 days. This helps maintain moisture and flavor while preventing the panko topping from becoming too soggy.
Freezing
If you want to save some for later, freeze the casserole in an airtight container for up to 2 months. It’s best to freeze before baking. When you are ready to enjoy it, thaw overnight in the fridge.
Reheating
Reheat leftovers in a preheated 350°F oven covered with foil, to keep moisture, for about 20 minutes or until warmed through. For a fresh crunch on top, remove the foil in the last 5 minutes of reheating.
FAQs
Can I use frozen shrimp for this Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe?
Yes! Just make sure to thaw and drain the shrimp completely before cooking to avoid extra moisture in the casserole.
Is it possible to substitute the cheeses?
Absolutely. While cheddar and mozzarella provide the classic melty and sharp combo, you can experiment with gouda, Monterey Jack, or even pepper jack for a spicy kick.
Can I make this casserole gluten-free?
Yes, simply replace the panko bread crumbs with a gluten-free alternative like crushed gluten-free crackers or almond flour to keep the topping crisp.
How do I avoid overcooking the shrimp?
Cook the shrimp just until they turn opaque, about 30 seconds in boiling seasoned water, then remove immediately. Overcooked shrimp become rubbery and tough.
Can I add vegetables to this Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe?
Definitely! Chopped spinach, diced bell peppers, or even mushrooms can be folded in for extra nutrition and color.
Final Thoughts
There truly is nothing quite like a lovingly made Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe to bring people together and create moments of joy around the table. With its combination of creamy, cheesy richness and a crispy, buttery topping, it’s no wonder this dish quickly becomes a family favorite. So go ahead, give it a try, and watch your loved ones delight in every bite!
Print
Shrimp Casserole with Cheddar, Mozzarella, and Panko Topping Recipe
- Prep Time: 10 minutes
- Cook Time: 25 minutes
- Total Time: 35 minutes
- Yield: 8 servings
- Category: Main Dish
- Method: Baking
- Cuisine: American
Description
This Shrimp Casserole recipe is a quick and flavorful dish featuring succulent shrimp seasoned with Old Bay, coated in a creamy, cheesy mixture, topped with buttery panko breadcrumbs, and baked to golden perfection. Perfect for an easy weeknight dinner or a crowd-pleasing side, this casserole offers a delightful blend of textures and rich seafood flavor.
Ingredients
Shrimp and Seasoning
- 2 pounds large shrimp (21–24 count), peeled and deveined
- 1 tablespoon Old Bay seasoning, plus 1 tablespoon salt for cooking water
Creamy Mixture
- 2/3 cup mayonnaise
- 1/2 teaspoon garlic powder
- 1/2 teaspoon ground black pepper
- 4 ounces shredded mozzarella cheese
- 4 ounces shredded medium cheddar cheese
Topping
- 1 tablespoon butter, plus more to grease the pan
- 1/2 cup panko bread crumbs
Instructions
- Preheat and prep: Preheat your oven to 375°F (190°C) and grease a 2 1/2 quart casserole dish thoroughly with butter to prevent sticking and ensure an even bake.
- Cook shrimp: Bring a large pot of salted water to a boil, adding 1 tablespoon of Old Bay seasoning. Add the peeled and deveined shrimp and cook briefly until they turn opaque, about 30 seconds. Immediately drain the shrimp and transfer them into a mixing bowl to cool slightly.
- Combine ingredients: To the cooked shrimp, add mayonnaise, garlic powder, and ground black pepper. Stir well to evenly coat the shrimp with the creamy mixture. Next, fold in the shredded mozzarella and medium cheddar cheeses until everything is well combined. Transfer this mixture to the prepared casserole dish, spreading it evenly.
- Make topping: Melt 1 tablespoon of butter in a small pan or microwave. Stir in the panko bread crumbs until they are well coated with butter. Sprinkle this buttery breadcrumb mixture evenly over the shrimp and cheese layer in the casserole dish.
- Bake and broil: Bake the casserole uncovered in the preheated oven for 13 to 15 minutes, or until the internal temperature reaches 145°F and the mixture is bubbling. To achieve a golden, crispy topping, switch the oven to broil and broil the casserole for 1 to 2 minutes, watching closely to prevent burning.
- Rest and serve: Remove the casserole from the oven and let it rest for 15 minutes. This allows the flavors to meld and the dish to set, making it easier to serve. Enjoy your delicious shrimp casserole warm.
Notes
- Be careful not to overcook the shrimp when boiling; they should just turn opaque to stay tender.
- You can substitute the mayonnaise with Greek yogurt for a lighter option.
- For a gluten-free version, use gluten-free bread crumbs instead of panko.
- Resting the casserole before serving helps it firm up for cleaner slices.
- To add extra flavor, consider mixing in some finely chopped fresh parsley or green onions before baking.

